Irisin and Myostatin Levels in Patients with Graves' Disease

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• 作者：Mehmet Muhittin Yalcin^a ; ^{yalcin.muhittin@gmail.com} ; Mujde Akturk^a ; Yusuf Tohma^b ; Ethem Turgay Cerit^a ; Alev Eroglu Altinova^a ; Emre Arslan^a ; Ilhan Yetkin^a ; Fusun Balos Toruner^a
• 关键词：Irisin ; Myostatin ; Graves' disease ; Hyperthyroidism
• 刊名：Archives of Medical Research
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：47
• 期：6
• 页码：471-475
• 全文大小：164 K
• 卷排序：47

文摘

Skeletal muscle system, which is one of the primary targets for thyroid hormones, has an important role in energy metabolism. Some myokines such as irisin and myostatin have considerable effects on energy metabolism in addition to the musculoskeletal system. Our aim was to investigate circulating irisin and myostatin levels in patients with Graves' Disease (GD).MethodsThis study included 41 patients with GD who were in overt hyperthyroid status and 44 healthy subjects.ResultsSerum irisin levels were higher in patients with hyperthyroidism than in control group (p = 0.003). However, there was no statistical difference in myostatin levels between groups (p = 0.21). Irisin levels were positively correlated with free triiodothyronine (FT3), free thyroxine (FT4), thyrotropin receptor antibody (TRAb) (p = 0.03, p = 0.02, p = 0.02, respectively) and negatively correlated with thyroid-stimulating hormone (TSH) (p = 0.006) in both groups. In multiple regression analysis, the presence of GD was the only significant factor associated with serum irisin levels (β = 0.29, p = 0.01). Myostatin levels were positively correlated with age, body mass index (BMI), FT4, HOMA-IR (p = 0.001, p = 0.04, p = 0.003, p = 0.03, respectively) and negatively correlated with TSH (p = 0.01). Multiple regression analysis also revealed that age and FT4 were the significant factors associated with circulating myostatin levels (β = 0.27, p = 0.02; β = 0.22, p = 0.04, respectively).ConclusionOur results suggest that increased irisin levels might contribute to altered energy metabolism in hyperthyroidism. Further studies to determine whether myostatin is affected due to hyperthyroidism are needed.