Poxviruses Encode a Reticulon-Like Protein that Promotes Membrane Curvature
详细信息 查看全文
- 作者：Karl J. Erlandson1 ; 4 ; Himani Bisht1 ; 4 ; 5 ; Andrea S. Weisberg1 ; Seong-In Hyun1 ; Bryan T. Hansen2 ; Elizabeth R. Fischer2 ; Jenny E. Hinshaw3 ; Bernard Moss1 ; bmoss@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：8 March 2016
- 年：2016
- 卷：14
- 期：9
- 页码：2084-2091
- 全文大小：4448 K
文摘
- •
Predicted structure of poxvirus A17 protein resembles ER tubule-forming reticulons
- •
Purified A17 protein interacts with lipids to form 25 nm vesicles and tubules
- •
Overexpression of A17 transforms the ER into a highly curved, tightly packed network
- •
A17 contributes to curvature during viral membrane biogenesis from the ER