Erythrocytes were incubated for up to 72 h in 5 mM, 45 mM and 100 mM glucose.
High glucose concentrations intensified lipid peroxidation.
High glucose attenuated hemolysis, eryptosis, Ca2+ accumulation and glutathione loss.
Glucose is a glycating agent but also energy source.
Results of exposure to high glucose should be interpreted with care.