Juvenile systemic lupus erythematosus (jSLE): Auditory pathway affection in relation to disease activity

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• 作者：M.A. Kotait^a ; H.H. Abd Elnabi^b ; T.A. Gabr^a ; ^{takwagabr@gmail.com}
• 关键词：Juvenile systemic lupus erythematosus (jSLE) ; Cognitive function ; SLEDAI ; Disease activity ; Mismatch negativity
• 刊名：International Journal of Pediatric Otorhinolaryngology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：93
• 期：Complete
• 页码：150-156
• 全文大小：637 K
• 卷排序：93

文摘

Juvenile Systemic lupus erythematosus (jSLE) is an autoimmune disease with the potential to affect a variety of organs in children or adolescents. jSLE is characterized by its severity and more widespread organ involvement specially central nervous system.ObjectivesTo evaluate auditory processing and cognitive functions in children and adolescents with SLE taking into consideration the disease severity.MethodsThis work included 40 normal hearing pediatric patients diagnosed as SLE (23 with active disease and 17 with inactive disease) and a control group included 30 matched healthy children. The methodology included basic audiologic evaluation, mismatch negativity (MMN) in response to speech and tone stimuli and memory tests.ResultsChildren with jSLE showed impaired hearing thresholds. They also showed impaired MMN recording in response to speech or tone stimuli with impaired memory subtests.ConclusionsPeripheral and central auditory systems are affected in jSLE. This affection is worse with active disease.