J-dot targeting of an exported HSP40 in Plasmodium falciparum-infected erythrocytes
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- 作者：Wiebke Petersena ; b ; e ; Simone Kü ; lzera ; c ; Sonja Engelsa ; Qi Zhanga ; Alyssa Ingmundsonb ; e ; Melanie Rugd ; Alexander G. Maierc ; Jude M. Przyborskia ; Przybors@biologie.uni-marburg.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Malaria ; Erythrocyte ; HSP40 ; HSP70 ; Plasmodium falciparum ; J-dot ; Protein targeting ; Chaperone
- 刊名：International Journal for Parasitology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：46
- 期：8
- 页码：519-525
- 全文大小：1047 K
文摘
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We examine the targeting of exported HSP40 to J-dots.
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We found that the substrate binding domain (SBD) is necessary and required for J-dot targeting.
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Targeting is independent of endogenous protein.
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The minimal construct associates with the exported chaperone PfHsp70x.
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J-dots are likely Plasmodium falciparum-specific.