Glycophorins, Blood Groups, and Protection from Severe Malaria

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• 作者：Samuel C. Wassmer¹ ; ^{Samuel.Wassmer@nyumc.org" class="auth_mail" title="E-mail the corresponding author} ; Jane M. Carlton²
• 关键词：Plasmodium falciparum malaria ; genome-wide association study
• 刊名：Trends in Parasitology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：32
• 期：1
• 页码：5-7
• 全文大小：572 K

文摘

In Malaŵi, Malungo alibe odi is a saying that translates as: ‘Malaria does not ask permission before coming in’. The recent finding of a new severe malaria resistance locus next to a cluster of glycophorin genes involved in Plasmodium falciparum erythrocyte invasion seems to suggest otherwise: that evolutionary pressure is enabling erythrocytes to lock the door to keep malaria out.