CMS downregulates Nrf2 pathway and increases lipid peroxidation in the PFC of rats.
Nrf2 pathway is involved in the oxido/nitrosative damage found in the PFC after CMS.
20">Nrf2 downregulation can be partially modulated by the treatment with antidepressants.
25">Nrf2 pathway is differentially regulated by antidepressants in PFC and hippocampus.
The antioxidant factor Nrf2 could be considered a potential therapeutic target.