Phytomedicine—Modulating oxidative stress and the tumor microenvironment for cancer therapy

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• 作者：Yu-Ting Cheng^a ; ^b ; ^c ; ¹ ; Chun-Chih Yang^b ; ^d ; ¹ ; Lie-Fen Shyur^a ; ^b ; ^c ; ^d ; ^e ; ^{lfshyur@ccvax.sinica.edu.tw}
• 关键词：CAF ; cancer-associated fibroblast ; COX ; cyclooxygenase ; CYP ; cytochrome P450 ; ECM ; extracellular matrix ; EMT ; epithelial-to-mesenchymal transition ; GPx ; glutathione peroxidase ; HIF-1 ; hypoxia-inducible transcription factor-1 ; JNK ; c-Jun NH2-terminal kinase ; MDSCs ; myeloid-derived suppressor cells ; MMP ; matrix metalloproteinase ; NF-κB ; nuclear factor-κB ; Nrf2 ; nuclear factor (erythroid-derived 2)-like 2 ; OS ; oxidative stress ; PCD ; programmed cell death ; ROS ; reactive oxygen species ; SOD ; superoxi
• 刊名：Pharmacological Research
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：114
• 期：Complete
• 页码：128-143
• 全文大小：2484 K
• 卷排序：114

文摘

In spite of the current advances and achievements in systems biology and translational medicinal research, the current strategies for cancer therapy, such as radiotherapy, targeted therapy, immunotherapy and chemotherapy remain palliative or unsatisfactory due to tumor metastasis or recurrence after surgery/therapy, drug resistance, adverse side effects, and so on. Oxidative stress (OS) plays a critical role in chronic/acute inflammation, carcinogenesis, tumor progression, and tumor invasion/metastasis which is also attributed to the dynamic and complex properties and activities in the tumor microenvironment (TME). Re-educating or reprogramming tumor-associated stromal or immune cells in the TME provides an approach for restoring immune surveillance impaired by disease in cancer patients to increase overall survival and reduce drug resistance. Herbal medicines or plant-derived natural products have historically been a major source of anti-cancer drugs. Delving into the lore of herbal medicine may uncover new leads for anti-cancer drugs. Phytomedicines have been widely documented to directly or indirectly target multiple signaling pathways and networks in cancer cells. A combination of anti-cancer drugs and polypharmacological plant-derived extracts or compounds may offer a significant advantage in sensitizing the efficacy of monotherapy and overcoming drug-induced resistance in cancer patients. This review introduces several phytochemicals and phytoextracts derived from medicinal plants or dietary vegetables that have been studied for their efficacy in preclinical cancer models. We address the underlying modes of action of induction of OS and deregulation of TME-associated stromal cells, mediators and signaling pathways, and reference the related clinical investigations that look at the single or combination use of phytochemicals and phytoextracts to sensitize anti-cancer drug effects and/or overcome drug resistance.