H1:IC31 vaccination is safe and induces long-lived TNF-α⁺IL-2⁺CD4 T cell responses in M. tuberculosis infected and uninfected adolescents: A randomized trial

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• 作者：Helen Mearns^a ; ¹ ; Hennie D. Geldenhuys^a ; ¹ ; Benjamin M. Kagina^a ; ² ; Munyaradzi Musvosvi^a ; Francesca Little^b ; Frances Ratangee^a ; Hassan Mahomed^a ; ³ ; Willem A. Hanekom^a ; Sø ; ren T. Hoff^c ; Morten Ruhwald^c ; Ingrid Kromann^c ; Peter Bang^c ; Mark Hatherill^a ; Peter Andersen^c ; Thomas J. Scriba^a ; ^{Thomas.scriba@uct.ac.za} ; the THYB04 study group⁴ ; Virginie Rozot^a ; Deborah A. Abrahams^a ; Katya Mauff^b ; Erica Smit^a ; Yolande Brown^a ; E. Jane Hughes^a ; ⁵ ; Edward Makgotlho^a ; ⁶ ; Alana Keyser^a ; Mzwandile Erasmus^a ; Lebohang Makhethe^a ; Hadn Africa^a ; Charles Hopley^a ; Marcia Steyn^a
• 关键词：Randomised ; Clinical trial ; H1 ; IC31 ; Mycobacterium tuberculosis ; Adolescents ; Vaccine ; ESAT-6 ; Ag85B
• 刊名：Vaccine
• 出版年：2017
• 出版时间：3 January 2017
• 年：2017
• 卷：35
• 期：1
• 页码：132-141
• 全文大小：1336 K
• 卷排序：35

文摘

H1:IC31 vaccination was well tolerated and had an acceptable safety profile. Two vaccinations of 15 μg H1:IC31 induced the most durable immune response. H1:IC31 induced long-lived memory CD4 T cells that co-express TNFα and IL-2.