文摘
Uterine endometrial stromal cells (ESCs) proliferate rapidly both in vivo and in vitro. ESCs proliferated in vitro in an autocrine fashion. Proliferation of mouse ESCs was prominently suppressed by inhibitors of lysophosphatidic acid (LPA) signaling. LPA receptors, LPA1 and LPA3, had redundant role in supporting the proliferation of ESCs.