Reduced graphene oxide conjugated with CuInS₂/ZnS nanocrystals with low toxicity for enhanced photothermal and photodynamic cancer therapies

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• 作者：Qiang Wu^a ; Maoquan Chu^a ; ^{mqchu98@tongji.edu.cn" class="auth_mail" title="E-mail the corresponding author} ; Yuxiang Shao^a ; Fangjie Wo^a ; Donglu Shi^b ; ^c
• 刊名：Carbon
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：108
• 期：Complete
• 页码：21-37
• 全文大小：4362 K

文摘

Graphene nanosheets have multiple uses including the removal of heavy metal ions and cancer photothermal therapy (PTT). Herein, we synthesized CuInS₂/ZnS nanocrystals and found that these nanocrystals exhibited both photothermal and photodynamic therapies (PTT and PDT). To improve the biological safety and cancer therapy efficiency of the CuInS₂/ZnS nanocrystals, they were incorporated into reduced graphene oxide (rGO) nanosheets using PEGylated liposome as linking reagent. The results showed that the toxicity of the CuInS₂/ZnS/liposome-rGO nanocomposites could be significantly lower than that of the CuInS₂/ZnS/liposome for less leaking of Cu²⁺ ions from the nanocomposites. In addition, the CuInS₂/ZnS/liposome-rGO combined the advantages of its components and strongly exhibited both photothermal conversion and photodynamic properties. The CuInS₂/ZnS/liposome-rGO nanocomposites upon 671-nm laser irradiation were highly efficient at inducing apoptosis in human esophagus carcinoma cells in vitro, and reducing the size of tumors (grown from esophageal cancer Eca-109 cells) in mice. The novel nanocomposites containing graphene developed in this work will have potential in medical therapy due to their low toxicity and highly efficient synergistic PTT and PDT properties.