An overlooked horticultural crop, Smyrnium olusatrum, as a potential source of compounds effective against African trypanosomiasis

详细信息    查看全文

• 作者：Riccardo Petrelli^a ; ¹ ; Farahnaz Ranjbarian^b ; ¹ ; Stefano Dall'Acqua^c ; Fabrizio Papa^d ; Romilde Iannarelli^a ; Stephane L. Ngahang Kamte^a ; Sauro Vittori^a ; Giovanni Benelli^e ; Filippo Maggi^a ; ^{filippo.maggi@unicam.it} ; Anders Hofer^b ; Loredana Cappellacci^a
• 关键词：Apiaceae ; Essential oil ; Isofuranodiene ; Trypanosoma brucei ; Wild celery
• 刊名：Parasitology International
• 出版年：2017
• 出版时间：April 2017
• 年：2017
• 卷：66
• 期：2
• 页码：146-151
• 全文大小：325 K
• 卷排序：66

文摘

Smyrnium olusatrum essential oils were evaluated against Trypanosma brucei. Their inhibitory activity was noteworthy (IC50 range was 1.9–4.0 μg/ml). The most active oil component was isofuranodiene (IC50 0.65 μg/ml). β-Acetoxyfuranoeudesm-4(15)-ene increased the parasite sensitivity. Germacrone was ineffective against the parasite.