Fipronil sulfone induced higher cytotoxicity than fipronil in SH-SY5Y cells: Protection by antioxidants
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- 作者：A. Romero ; E. Ramos ; I. Ares ; V. Castellano ; M. Martí ; nez ; M.R. Martí ; nez-Larrañ ; aga ; A. Anadó ; n ; anadon@vet.ucm.es" class="auth_mail" title="E-mail the corresponding author ; M.A. Martí ; nez
- 关键词：NO ; nitric oxide ; NAC ; N-acetyl-cysteine ; MEL ; melatonin ; MDA ; malondialdehyde ; TBARS ; thiobarbituric acid reactive substance ; DMSO ; dimethylsulphoxide ; SDS ; sodium dodecyl sulfate ; EMEM ; Eagle&rsquo ; s minimum essential medium ; FBS ; fetal bovine serum ; MTT ; 3-[4 ; 5 dimethylthiazol-2-yl]-2 ; 5-diphenyl-tetrazolium bromide ; Tempol ; (4-hydroxy-Tempo ; 4-hydroxy-2 ; 2 ; 6 ; 6-tetramethylpiperidine N-oxyl) ; Trolox ; [(± ; )-6-hydroxy-2 ; 5 ; 7 ; 8-tetramethylchromane-2-carboxylic acid]
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：11 June 2016
- 年：2016
- 卷：252
- 期：Complete
- 页码：42-49
- 全文大小：1899 K
文摘
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Fipronil sulfone metabolite was more cytotoxic than fipronil in SH-SY5Y cells.
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Fipronil and fipronil sulfone induced NO and MDA production in SH-SY5Y cells.
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Antioxidant compounds ameliorated fipronil and fipronil sulfone cytotoxicity.