Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of Tb>Hb>17 cells

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• 作者：Myoung Seok Ko ; Hyo Jeong Kim ; Hong Kyung Kim ; Nal Ae Yoon ; Unn Hwa Lee ; Sang Chul Lee ; Dae Kyun Chung ; Byung Ju Lee ; Jae Hee Suh ; Wha Ja Cho ; Jeong Woo Park
• 关键词：DRG2 ; EAE ; TH17 ; NF-魏B ; PPAR纬 ; IL-6
• 刊名：Clinical Immunology
• 出版年：February, 2014
• 年：2014
• 卷：150
• 期：2
• 页码：225-235
• 全文大小：845 K

文摘

Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of DRG2 in EAE was mediated by the inhibition of the development of Tb>Hb>17 cells. DRG2 enhanced the activity of PPAR纬, which led to an inhibition of the nuclear factor kappa B (NF-魏B) activity and IL-6 production in antigen presenting cells and an inhibition of the development of Tb>Hb>17 cells. Our results demonstrate that DRG2 is an essential modulator of EAE.