A recombinant DNA vaccine protects mice deficient in the alpha/beta interferon receptor against lethal challenge with Usutu virus
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- 作者：Miguel A. Martí ; n-Acebesa ; b ; Ana-Belé ; n Blá ; zqueza ; Rodrigo Cañ ; as-Arranzb ; Á ; ngela Vá ; zquez-Calvoa ; Teresa Merino-Ramosa ; Estela Escribano-Romeroa ; Francisco Sobrinob ; Juan-Carlos Saiza ; jcsaiz@inia.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Flavivirus ; Usutu virus ; DNA vaccine ; IFNAR mice ; Antibodies
- 刊名：Vaccine
- 出版年：2016
- 出版时间：19 April 2016
- 年：2016
- 卷：34
- 期：18
- 页码：2066-2073
- 全文大小：1847 K
文摘
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We engineered a plasmid encoding Usutu virus prM and E proteins.
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Expression of Usutu virus prM and E proteins induces the formation of VLPs.
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Vaccination with this plasmid protects mice deficient in the alpha/beta interferon receptor IFNAR (−/−) against infection.
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IFNAR (−/−) mice provide a useful model to study vaccines against Usutu virus.