The dopamine D4 receptor gene 48-base-pair-repeat polymorphism and mood disorders: A meta-analysis

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• 作者：Ló ; pez Leó ; n ; Sandra ; Croes ; Esther A. ; Sayed-Tabatabaei ; Fakhredin A. ; Claes ; Stephan ; et. al.
• 刊名：Biological Psychiatry
• 出版年：2005
• 出版时间：May 1, 2005
• 年：2005
• 卷：57
• 期：9
• 页码：999-1003
• 全文大小：224 K

文摘

ass=""h4"">Background

We conducted a meta-analysis to re-evaluate the role of the dopamine D4 receptor gene 48-base-pair- repeat (DRD4) polymorphism in mood disorders.

ass=""h4"">Methods

DRD4 allele frequencies were compared between 917 patients with unipolar (UP) or bipolar affective disorder (BP) and 1164 control subjects from 12 samples, using the Cochrane Review Manager.

ass=""h4"">Results

An association was found between all mood disorder groups and DRD4.2. After correcting for multiple testing, the association between DRD4.2 and BP dropped to insignificance; however, the evidence of an association between the DRD4.2 allele and UP (p < .001) and the combined group (p < .001) remained. There was no evidence for heterogeneity or publication bias.

ass=""h4"">Conclusions

These findings suggest that the DRD4.2 allele is a risk allele for depression symptomatology. Meta-analysis may be a valuable objective tool for a quantitative summary of evidence for association studies in psychiatric genetics.