Normal range of serum Amphiregulin in healthy adult human females

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• 作者：Esther A. Peterson ^{esther.peterson@einstein.yu.edu} ; Shabana Shabbeer ^{shabana.shabbeer@gmail.com} ; Paraic A. Kenny ; ^{paraic.kenny@einstein.yu.edu}
• 关键词：Serum biomarker ; Epidermal Growth Factor Receptor ; Cytokine ; Breast cancer ; Amphiregulin
• 刊名：Clinical Biochemistry
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：45
• 期：6
• 页码：460-463
• 全文大小：366 K

文摘

Objectives

Prior to large studies in breast cancer patients, we have sought to establish the normal range of a potential serum biomarker, Amphiregulin, in healthy women and to determine whether sampling during the menstrual cycle influences the detected Amphiregulin levels.

Design and methods

Serum Amphiregulin levels were quantified using a commercially available ELISA in 85 normal female donors.

Results

The range of circulating Amphiregulin was 0-4467 pg/mL. The majority of women had no detectable circulating Amphiregulin (n = 54), and only five women had levels exceeding 500 pg/mL. Serum Amphiregulin levels did not vary significantly during the menstrual cycle (n = 7 women).

Conclusions

Detection of circulating Amphiregulin in a significant minority of healthy women suggests that it may not have the specificity necessary for a population screening tool; however its potential utility for monitoring response to treatment or disease progression should be examined in breast cancer cases.