Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities
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- 作者：Nittaya Boonmuena ; b ; Ping Gonga ; Zulfiqar Alic ; Amar G. Chittiboyinac ; Ikhlas Khanc ; Daniel R. Doerged ; William G. Helferiche ; Kathryn E. Carlsonf ; Teresa Martinf ; Pawinee Piyachaturawatb ; g ; John A. Katzenellenbogenf ; Benita S. Katzenellenbogena ; katzenel@illinois.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：E2 ; estradiol ; Iso-Liq ; isoliquiritigenin ; Liq ; liquiritigenin ; RBA ; relative binding affinity ; SERM ; selective estrogen receptor modulator
- 刊名：Steroids
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：105
- 期：Complete
- 页码：42-49
- 全文大小：606 K
文摘
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Licorice root dietary supplements are sometimes used as a natural alternative to HRT.
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The 9 licorice root extract components bind to estrogen receptors with low affinity.
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The compounds have estrogen agonist and/or antagonist activity, akin to SERMs.
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All agonist and/or antagonist activities were estrogen receptor dependent.