Isoliquiritigenin exhibits anti-proliferative properties in the pituitary independent of estrogen receptor function

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• 作者：Karen E. Weis ; Lori T. Raetzman ; ^{raetzman@life.illinois.edu}
• 关键词：Pituitary development ; Isoliquiritigenin ; Proliferation ; Estrogen
• 刊名：Toxicology and Applied Pharmacology
• 出版年：2016
• 出版时间：15 December 2016
• 年：2016
• 卷：313
• 期：Complete
• 页码：204-214
• 全文大小：1489 K
• 卷排序：313

文摘

Isoliquiritigenin possesses weak estrogenic activity based on induction of Cckar. ISL can be anti-proliferative in pituitary explants without altering cell lineages. Anti-proliferative behavior of ISL is not estrogen receptor mediated. ISL induces p21 expression leading to cell cycle arrest and apoptosis.