Correlation between the alterations in the mRNA expressions of the α₁-adrenoceptor and estrogen receptor subtypes in the pregnant human uterus and cervix

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• 作者：Eszter Ducza ; Zsolt Kormá ; nyos ; Bé ; la Endre Resch and George Falkay
• 刊名：European Journal of Pharmacology
• 出版年：2005
• 出版时间：28 December 2005
• 年：2005
• 卷：528
• 期：1-3
• 页码：183-187
• 全文大小：262 K

文摘

Our present aim was to determine the association between the mRNA expressions of the estrogen and adrenoceptor subtypes in the pregnant human uterus and cervix. The presence of the mRNA expressions of all the α₁-adrenoceptor and estrogen receptor subtypes in the uterus and cervix was proved by means of a reverse transcription polymerase chain reaction method, with a predominance of the mRNAs of the α_1B-adrenoceptor and estrogen α receptors, respectively. The change in the mRNA expression of the estrogen receptor α correlated strongly with the change in mRNA level of the α_1B-adrenoceptors. We presume that the expression of the α_1B-adrenoceptors at 33–34 weeks in the pregnant human uterus is regulated by estrogen through the estrogen receptor α subtypes.