Targeting mast cells: Uncovering prolific therapeutic role in myriad diseases
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- 作者：Jatinder Singh1 ; Ramanpreet Shah1 ; Dhandeep Singh ; ddd300@gmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：AP1 ; Activator protein 1 ; cAMP ; Cyclic adenosine monophoshate ; CXCR ; Cytokine receptors ; CRTH2 ; Chemoattractant receptor-homologous molecule expressed on Th2 cells ; DAMPs ; Damage-associated molecular pattern ; EtBr ; Ethidium Bromide ; IgE ; Immunoglobulin E ; IKK ; IκB kinase ; IRF3 ; Interferon regulatory factor 3 ; LAT ; linker for activation of T cells ; LYN ; Tyrosine-protein kinase ; MAP3Ks ; Mitogen-activated protein kinase kinase kinases ; NFκB ; Nuclear factor kappa B ; NTAL ; Non-T-cell activation linke
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：40
- 期：Complete
- 页码：362-384
- 全文大小：2704 K
文摘
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Therapeutic role of mast cells in myriad diseases.
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Inflammatory mediators have role in various diseases like asthma, cancer.
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CRTH2 antagonists showed anti-asthma and anti-allergic rhinitis activity.
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H4 antagonists have been used in pruritis and rhinitis treatment.
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Considerable difference exist between human and murine mast cells.