Construction of quinoline-fused lactones and 2,3-disubstituted quinolines via catalytic aerobic sp³ C-H oxidation: application of fragment-reassembly strategy

详细信息    查看全文

• 作者：Xingge Ma ; Yingzu Zhu ; Shiwei Lü ; Liang Zhang ; Liangliang Luo ; Xiaodong Jia
• 关键词：Radical cation salt ; C&ndash ; H oxidation ; Quinoline ; Heterocycles ; Lactone
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：6 April 2016
• 年：2016
• 卷：57
• 期：14
• 页码：1528-1531
• 全文大小：772 K

文摘

Designed by fragment-reassembly strategy, the reaction between glycine esters and cyclic enol ethers was achieved in the catalysis of TBPA^+·/O₂, yielding a series of quinoline-fused lactones and 2,3-disubstituted quinolines. This approach provided an efficient method to construct quinoline skeleton, in which two new rings and two new C–C bonds were built in one pot.