Effects of antiandrogenic progestins, chlormadinone and cyproterone acetate, and the estrogen 17α-ethinylestradiol (EE2), and their mixtures: Transactivation with human and rainbowfish hormone receptors and transcriptional effects in zebrafish (Danio rerio) eleuthero-embryos
文摘
Agonistic and antagonistic activity of CMA and CPA were assessed in vitro. CMA and CPA showed different interaction with human and fish receptors. No progestogenic but antiandrogenic and antiglucocorticoid activity occurred in fish. CMA and CPA showed transcriptional changes in zebrafish embryos. Binary mixtures of the progestins with EE2 were assessed in vitro and in vivo.