Activity of coumarin-oxadiazole-appended phenol in inhibiting DNA oxidation and scavenging radical
详细信息 查看全文
- 作者：Xiao-Rui Gong ; Gao-Lei Xi ; Zai-Qun Liu ; zaiqun-liu@jlu.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：Coumarin ; Oxadiazole ; Antioxidant ; Oxidation of DNA ; Free radical
- 刊名：Tetrahedron Letters
- 出版年：2015
- 出版时间：4 November 2015
- 年：2015
- 卷：56
- 期：45
- 页码：6257-6261
- 全文大小：517 K
文摘
Fourteen coumarin–oxadiazole-appended phenols were synthesized, while halogen atom, methoxyl, and hydroxyl groups acted as the functional groups for testing the ability to trap 2,2′-azinobis(3-ethylbenzothiazoline-6-sulfonate) cationic radical (ABTS+
) and to inhibit the oxidation of DNA caused by 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) and Cu2+/glutathione (GSH). The coumarin–oxadiazole-appended phenols containing the hydroxyl group were able to inhibit AAPH-induced oxidation of DNA and to quench ABTS+, and the antioxidant effectiveness depended upon the number of hydroxyl groups. Moreover, the coumarin–oxadiazole-appended phenols used herein were able to inhibit Cu2+/GSH-induced oxidation of DNA, and the inhibitory effect generated by bromide was similar to that of the hydroxyl group. In particular, the antioxidant effectiveness of para-bromide at the benzene ring even approached to that of Trolox.
) and to inhibit the oxidation of DNA caused by 2,2′-azobis(2-amidinopropane hydrochloride) (AAPH) and Cu2+/glutathione (GSH). The coumarin–oxadiazole-appended phenols containing the hydroxyl group were able to inhibit AAPH-induced oxidation of DNA and to quench ABTS+, and the antioxidant effectiveness depended upon the number of hydroxyl groups. Moreover, the coumarin–oxadiazole-appended phenols used herein were able to inhibit Cu2+/GSH-induced oxidation of DNA, and the inhibitory effect generated by bromide was similar to that of the hydroxyl group. In particular, the antioxidant effectiveness of para-bromide at the benzene ring even approached to that of Trolox.