Loss of Gdf-15 aggravates 6-OHDA lesion-mediated cell death of DAergic neurons.
Gdf-15−/− mice exhibit reduced numbers of microglia following 6-OHDA administration.
Gdf-15−/− mice show a differential cytokine expression pattern post-6-OHDA lesion.
Gdf-15 mediates lesioned DAergic neuron survival, possibly in a direct neurotrophic supportive manner.