A systematic review of the protective role of swertiamarin in cardiac and metabolic diseases

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• 作者：Xin Yu Leong¹ ; Punniyakoti Veeraveedu Thanikachalam ; ¹ ; ^{punniyakoti@imu.edu.my} ; Manisha Pandey ; Srinivasan Ramamurthy ; ^{srinivasan_ramamurthy@imu.edu.my}
• 关键词：AA ; adjuvant arthritis ; ABTS ; 2 ; 2-azino-bis(3-Ethylbenzothiazoline-6-sulfonic acid) diammonium salt ; ACC ; acetyl-CoA-carboxylase ; ALP ; alkaline phosphatase ; CAT ; catalase ; CK-MB ; creatinine kinase type muscle brain ; Con A ; concanavalin A ; CPT-1α ; carnitine palmitoyl transferase-1α ; D-GaIN ; D-galactosamine ; DN ; diabetic nephropathy ; DTH ; delayed type hypersensitivity ; FFA ; free fatty acid ; FLS ; fibroblast-like synoviocytes ; GSH ; glutathione ; HA ; hemagglutinating antibody ; HbA1c ; glycated hemoglob
• 刊名：Biomedicine & Pharmacotherapy
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：84
• 期：Complete
• 页码：1051-1060
• 全文大小：979 K
• 卷排序：84

文摘

Swertiamarin, is a secoiridoid glycoside found in genera of Enicostemma Species (Enicostemma littorale and Enicostemma axillare) belonging to the family of gentianaceae, which has been reported to cure many diseases such as diabetes, hypertension, atherosclerosis, arthritis, malaria and abdominal ulcers. However, to the best of our knowledge, till date systematic studies to understand the molecular basis of cardiac and metabolic disease preventing properties of swertiamarin has not been reported.Aim of the reviewThe present review aims to compile an up-to-date information on the progress made in the protective role of swertiamarin in cardiac and metabolic diseases with the objective of providing a guide for future research on this bioactive molecule.Materials and methodsInformation on the swertiamarin was collected from major scientific databases (Pubmed, Springer, google scholar, and Web of Science) for publication between1974-2016. In this review, the protective role of swertiamarin on cardiac and metabolic diseases was discussed.ResultsSwertiamarin reported to exhibit a wide range of biological activities such as anti-atherosclerotic, antidiabetic, anti-inflammatory and antioxidant effects. These activities were mainly due to its effect on various signaling pathways associated with cardiac remodeling events such as inhibition of NF-kB expression, LDL oxidation, apoptosis, inflammatory and lipid peroxidation markers and stimulation of antioxidant enzymes.ConclusionSweriamarin exhibit a wide range of biological activities. This review presents evidence supporting the point of view that swertiamarin should be considered a potential therapeutic agent against cardiac and metabolic diseases, giving rise to novel applications in their prevention and treatment.