Immune responses against hepatitis C virus genotype 3a virus-like particles in mice: A novel VLP prime-adenovirus boost strategy
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- 作者：Anuj Kumara ; 1 ; Soma Dasb ; 1 ; Ranajoy Mullicka ; Priyanka Lahiria ; Ranjitha Tatinenia ; Debashree Goswamia ; Prasanna Bhata ; Joseph Torresic ; Eric James Gowansd ; Anjali Anoop Karandeb ; Saumitra Dasa ; sdas@mcbl.iisc.ernet.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：EDTA ; ethylenediaminetetra-acetic acid ; ELISA ; enzyme-linked immunosorbent assay ; GAPDH ; glyceraldehyde 3-phosphate dehydrogenase ; gt ; genotype ; HCV ; hepatitis C virus ; HCV-LPs ; hepatitis C virus-like particles ; IRES ; internal ribosome entry site ; NP40 ; nonidet P-40 ; PBS ; Phosphate buffered saline ; PMSF ; phenylmethyl-sulfonyl fluoride ; RT-PCR ; reverse transcription-polymerase chain reaction ; SCID/uPA ; severe combined immune deficient/urokinase-type plasminogen activator ; TEM ; transmission electr
- 刊名：Vaccine
- 出版年：2016
- 出版时间：17 February 2016
- 年：2016
- 卷：34
- 期：8
- 页码：1115-1125
- 全文大小：2263 K
文摘
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Generated VLP based vaccine against HCV genotype-3a and 1b.
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Novel heterologous prime boost strategy eliciting high antibody and T cell response.
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Combined regimen of VLP followed by recombinant adenovirus could more effectively inhibit HCV infection.