Mono-(2-ethylhexyl) phthalate induces apoptosis through miR-16 in human first trimester placental cell line HTR-8/SVneo
详细信息 查看全文
- 作者：Sunitha Meruvu ; Jian Zhang ; Yudhishtar Singh Bedi ; Mahua Choudhury ; mchoudhury@pharmacy.tamhsc.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：Mono-(2-ethylhexyl) phthalate ; Apoptosis ; miR-16 ; 1st trimester trophoblast cells ; Pregnancy complications
- 刊名：Toxicology in Vitro
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：31
- 期：Complete
- 页码：35-42
- 全文大小：1072 K
文摘
- •
MEHP induces miR-16 expression in the 1st trimester placental cell line, HTR8/SVneo.
- •
Upregulation of miR-16 decreased BCL-2 mRNA and protein expression.
- •
Inhibition of miR-16 attenuated apoptosis by increasing BCL-2/BAX ratio in the MEHP exposed cells
- •
20">Early exposure to phthalates may cause placental cell apoptosis through miR-16, leading to pregnancy complications.