Commandeering Channel Voltage Sensors for Secretion, Cell Turgor, and Volume Control

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• 作者：Rucha Karnik¹ ; Sakharam Waghmare¹ ; Ben Zhang¹ ; Emily Larson¹ ; Cé ; cile Lefoulon¹ ; Wendy Gonzalez² ; Michael R. Blatt¹ ; ^{michael.blatt@glasgow.ac.uk}
• 关键词：plant cell turgor ; volume control ; K+ channels ; voltage-dependent ; SNARE protein ; Sec1-Munc18 protein ; secretion
• 刊名：Trends in Plant Science
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：22
• 期：1
• 页码：81-95
• 全文大小：3336 K
• 卷排序：22

文摘

Control of cell volume and osmolarity is central to cellular homeostasis in all eukaryotes. It lies at the heart of the century-old problem of how plants regulate turgor, mineral and water transport. Plants use strongly electrogenic H+-ATPases, and the substantial membrane voltages they foster, to drive solute accumulation and generate turgor pressure for cell expansion. Vesicle traffic adds membrane surface and contributes to wall remodelling as the cell grows. Although a balance between vesicle traffic and ion transport is essential for cell turgor and volume control, the mechanisms coordinating these processes have remained obscure. Recent discoveries have now uncovered interactions between conserved subsets of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) proteins that drive the final steps in secretory vesicle traffic and ion channels that mediate in inorganic solute uptake. These findings establish the core of molecular links, previously unanticipated, that coordinate cellular homeostasis and cell expansion.