“Brains on a chip‿ Towards engineered neural networks
详细信息 查看全文
- 作者：Mathias J. Aebersold1 ; Harald Dermutz1 ; Csaba Forró ; 1 ; Serge Weydert1 ; Greta Thompson-Steckel ; Já ; nos Vö ; rö ; s ; janos.voros@biomed.ee.ethz.ch" class="auth_mail" title="E-mail the corresponding author ; Lá ; szló ; Demkó ; ; demko@biomed.ee.ethz.ch" class="auth_mail" title="E-mail the corresponding author
- 关键词：in vitro ; bottom-up ; neural network ; controlled topology ; cell placement ; axon guidance ; chemical surface patterning ; microstructure ; network behavior ; drug test
- 刊名：TrAC Trends in Analytical Chemistry
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：78
- 期：Complete
- 页码：60-69
- 全文大小：2366 K
文摘
- •
Neural networks with controlled topology as model systems for pharmaceutical testing.
- •
We summarize the different approaches available for engineering neural networks.
- •
Advances and limitations in terms of cell placement and axon guidance are discussed.
- •
We compare the network behavior of patterned and random in vitro neuronal networks.
- •
Their analytical value for studying the brain and neurological disorders is presented.