Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: A longitudinal study

详细信息    查看全文

• 作者：Breno Satler Diniz ; Charles F. Reynolds III ; Amy Begley ; Mary Am ; a Dew ; Stewart J. Anderson ; Francis Lotrich ; Kirk I. Erickson ; Oscar Lopez ; Howard Aizenstein ; Etienne L. Sibille ; Meryl A. Butters
• 关键词：BDNF ; Late-life depression ; Mild cognitive impairment ; Elderly ; Pathophysiology ; Dementia
• 刊名：Journal of Psychiatric Research
• 出版年：February, 2014
• 年：2014
• 卷：49
• 期：Complete
• 页码：96-101
• 全文大小：259 K

文摘

Changes in brain-derived neurotrophic factor (BDNF) level are implicated in the pathophysiology of cognitive decline in depression and neurodegenerative disorders in older adults. We aimed to evaluate the longitudinal association over two years between BDNF and persistent cognitive decline in individuals with remitted late-life depression and Mild Cognitive Impairment (LLD聽+聽MCI) compared to either individuals with remitted LLD and no cognitive decline (LLD聽+聽NCD) or never-depressed, cognitively normal, elderly control participants. We additionally evaluated the effect of double-blind, placebo-controlled donepezil treatment on BDNF levels in all of the remitted LLD participants (across the levels of cognitive function). We included 160 elderly participants in this study (72 LLD聽+聽NCD, 55 LLD聽+聽MCI and 33 never-depressed cognitively normal elderly participants). At the same visits, cognitive assessments were conducted and blood sampling to determine serum BDNF levels were collected at baseline assessment and after one and two years of follow-up. We utilized repeated measure, mixed effect models to assess: (1) the effects of diagnosis (LLD聽+聽MCI, LLD聽+聽NCD, and controls), time, and their interaction on BDNF levels; and (2) the effects of donepezil treatment (donepezil vs. placebo), time, baseline diagnosis (LLD聽+聽MCI vs. LLD聽+聽NCD), and interactions between these contrasts on BDNF levels. We found a significant effect of time on BDNF level (p聽=聽0.02) and a significant decline in BDNF levels over 2 years of follow-up in participants with LLD聽+聽MCI (p聽=聽0.004) and controls (p聽=聽0.04). We found no effect of donepezil treatment on BDNF level. The present results suggest that aging is an important factor related to decline in BDNF level.

Clinicaltrials.gov Identifier: .