Klebsiella pneumoniae blaKPC-3 nosocomial epidemic: Bayesian and evolutionary analysis

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• 作者：Silvia Angeletti^a ; ^{s.angeletti@unicampus.it} ; Alessandra Lo Presti^b ; Eleonora Cella^b ; ^c ; Marta Fogolari^a ; Lucia De Florio^a ; Etleva Dedej^a ; Aletheia Blasi^a ; Teresa Milano^d ; Stefano Pascarella^d ; Raffaele Antonelli Incalzi^e ; Roberto Coppola^f ; Giordano Dicuonzo^a ; Massimo Ciccozzi^a ; ^b
• 关键词：K. pneumoniae ; blaKPC-3 gene ; Bayesian analysis ; Evolutionary analysis
• 刊名：Infection, Genetics and Evolution
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：46
• 期：Complete
• 页码：85-93
• 全文大小：835 K
• 卷排序：46

文摘

Bayesian phylogenetic and selective pressure analysis of blakpc type 3 gene to follow the spread of K. pneumoniae clinical isolates in nosocomial setting. Homology modeling applied to the KPC-3 protein to evidence the influence of amino acid substitutions on the protein structure and substrate specificity. The evolutionary rate, the time-scaled phylogeny, the population dynamics analysis and the phylogeography. blaKPC gene can be applied to improve the epidemiological surveillance of antimicrobial resistance genes.