Effects of intracellular acidosis on endothelial function: An overview

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• 作者：Ettore Crimi ; MD^a ; Fabio Silvio Taccone ; MD^b ; Teresa Infante ; BiolD^c ; Sabino Scolletta ; MD^b ; Valeria Crudele ; BiolD^d ; Claudio Napoli ; MD ; PhD^c ; ^d ; ^{claudio.napoli@unina2.it}
• 关键词：Endothelium ; pH ; Intracellular ; Acidosis ; Regulation
• 刊名：Journal of Critical Care
• 出版年：2012
• 出版时间：April, 2012
• 年：2012
• 卷：27
• 期：2
• 页码：108-118
• 全文大小：442 K

文摘

The endothelium represents the largest functional organ in the human body playing an active role in vasoregulation, coagulation, inflammation, and microvascular permeability. Endothelium contributes to maintain vascular integrity, intravascular volume, and tissue oxygenation promoting inflammatory network response for local defense and repair. Acid-basis homeostasis is an important physiologic parameter that controls cell function, and changes in pH can influence vascular tone by regulating endothelium and vascular smooth muscle cells. This review presents a current perspective of the effects of intracellular acidosis on the function and the basic regulatory mechanisms of endothelial cells.