The GPIHBP1-LPL Complex Is Responsible for the Margination of Triglyceride-Rich Lipoproteins in Capillaries
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- 作者：Chris N. Goulbourne1 ; 10 ; Peter Gin1 ; 10 ; Angelica Tatar1 ; Chika Nobumori1 ; Andreas Hoenger2 ; Haibo Jiang3 ; Chris R.M. Grovenor3 ; Oludotun Adeyo1 ; Jeffrey D. Esko4 ; Ira J. Goldberg5 ; Karen Reue1 ; 6 ; Peter Tontonoz7 ; 8 ; André ; Bensadoun9 ; Anne P. Beigneux1 ; Stephen G. Young1 ; 6 ; sgyoung@mednet.ucla.edu" class="auth_mail ; Loren G. Fong1 ; lfong@mednet.ucla.edu" class="auth_mail
- 刊名：Cell Metabolism
- 出版年：6 May 2014
- 年：2014
- 卷：19
- 期：5
- 页码：849-860
- 全文大小：3535 K
文摘
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TRLs bind to capillaries of wild-type but not Gpihbp1–/– mice
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TRLs attach to endothelial cell membrane structures, which we have named nanovilli
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Endothelial cell-derived LPL does not restore defective binding in Gpihbp1–/– mice
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TRLs bind to the LPL–GPIHBP1 complex in the capillary lumen