Human cord blood endothelial progenitors promote post-ischemic angiogenesis in immunocompetent mouse model
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- 作者：Andrea Flexa ; 1 ; Federico Biscettib ; 1 ; Maria Grazia Iachininotoc ; Eugenia Rosa Nuzzoloc ; Nicoletta Orlandoc ; Sara Capodimontic ; Flavia Angelinia ; Caterina Giovanna Valentinic ; Maria Bianchic ; Luigi Maria Laroccad ; Maurizio Martinid ; 2 ; Luciana Teofilic ; 2 ; luciana.teofili@unicatt.it" class="auth_mail" title="E-mail the corresponding author
- 关键词：Endothelial progenitor cells ; Ischemia ; Graft rejection ; Angiogenic factors ; Immune tolerance
- 刊名：Thrombosis Research
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：141
- 期：Complete
- 页码：106-111
- 全文大小：1225 K
文摘
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Endothelial colony forming cells (ECFCs) are endowed with vascular regenerative ability.
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ECFC immunogenicity and susceptibility to rejection is unknown.
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We injected human ECFCs in the ischemic hindlimb of C57BL/6 J mice.
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Treatment promotes blood flow recovery and endogenous production of angiogenic factors.