miR-214 protects erythroid cells against oxidative stress by targeting ATF4 and EZH2
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- 作者：Ming Gaoa ; Yun Liua ; b ; Yue Chena ; c ; Chunyang Yina ; Jane-Jane Chend ; Sijin Liua ; sjliu@rcees.ac.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：ATF-4 ; activating transcription factor 4 ; Bim ; BCL2-like 11 ; EZH2 ; enhancer of zeste 2 polycomb repressive complex 2 subunit ; eIF2 ; eukaryotic initiation factor-2 ; Fe-NTA ; ferric nitrilotriacetate ; Hri ; eukaryotic translation initiation factor 2 alpha kinase 1 ; Nrf2 ; nuclear factor erythroid 2-related factor 2 ; ROS ; reactive oxygen species
- 刊名：Free Radical Biology and Medicine
- 出版年：2016
- 出版时间：March 2016
- 年：2016
- 卷：92
- 期：Complete
- 页码：39-49
- 全文大小：2402 K
文摘
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miR-214 was downregulated in erythroid cells upon various stresses.
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Nrf2 directly regulated miR-214 expression in erythroid cells.
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Nrf2–miR-214 pathway antagonized As-induced erythroid cell death.
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20">ATF4 and EZH2 were the downstream targets of Nrf2–miR-214 signaling.
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25">Bim was a downstream executor of miR-214–EZH2 signaling against As stress.