Trifluoromethylation of heterocycles via visible light photoredox catalysis

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• 作者：Naeem Iqbal ; Sungkyu Choi ; Euna Ko ; Eun Jin Cho ; ^{echo@hanyang.ac.kr}
• 关键词：Visible light ; Photoredox catalysis ; Trifluoromethylation ; Heterocycles ; Ruthenium
• 刊名：Tetrahedron Letters
• 出版年：2012
• 出版时间：11 April, 2012
• 年：2012
• 卷：53
• 期：15
• 页码：2005-2008
• 全文大小：755 K

文摘

A method has been developed for the visible light-induced trifluoromethylation of heterocyclic compounds. A variety of electron-rich heterocycles were transformed into trifluoromethylated products by using CF₃I as the trifluoromethyl radical source and Ru(bpy)₃Cl₂ as the photocatalyst under mild reaction conditions. This operationally simple and eco-friendly process can introduce trifluoromethyl groups without prefunctionalization.