6, 6′-Thiobis(methylene)-β-cyclodextrin dimer (β-CD-S-dimer) was synthesized.
The β-CD-S-dimer was used to enhance β-naphthoflavone’s water solubility.
The solubilized β-NF by complexation significantly induced the cytochrome P4501A1 activity.
β-NF supramolecular complex with β-CD-S-dimer enhanced the bio-functionality of β-NF.
Various instrumental analyses were performed to verify the formation of a supramolecular complex.