Enhancing bio-availability of β-naphthoflavone by supramolecular complexation with 6,6′-thiobis(methylene)-β-cyclodextrin dimer
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- 作者：Jae Min Choia ; jm.choi.25@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Eunae Choa ; 82goodgirl@hanmail.net" class="auth_mail" title="E-mail the corresponding author ; Benel Leeb ; formangel@naver.com" class="auth_mail" title="E-mail the corresponding author ; Daham Jeongb ; darkamir@nate.com" class="auth_mail" title="E-mail the corresponding author ; Youngjin Choic ; ojchoi@hoseo.edu" class="auth_mail" title="E-mail the corresponding author ; Jae-Hyuk Yud ; jyu1@wisc.edu" class="auth_mail" title="E-mail the corresponding author ; Seunho Jungb ; shjung@konkuk.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aryl hydrocarbon receptor agonist ; β-Naphthoflavone ; 6 ; 6&prime ; -thiobis(methylene)-β-cyclodextrin dimer ; Solubilization ; Complexation
- 刊名：Carbohydrate Polymers
- 出版年：2016
- 出版时间：20 October 2016
- 年：2016
- 卷：151
- 期：Complete
- 页码：40-50
- 全文大小：2755 K
文摘
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6, 6′-Thiobis(methylene)-β-cyclodextrin dimer (β-CD-S-dimer) was synthesized.
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The β-CD-S-dimer was used to enhance β-naphthoflavone’s water solubility.
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The solubilized β-NF by complexation significantly induced the cytochrome P4501A1 activity.
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β-NF supramolecular complex with β-CD-S-dimer enhanced the bio-functionality of β-NF.
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Various instrumental analyses were performed to verify the formation of a supramolecular complex.