EUS-guided celiac ganglion irradiation with iodine-125 seeds for pain control in pancreatic carcinoma: a prospective pilot study

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• 作者：Kai-Xuan Wang ; Zhen-Dong Jin ; Yi-Qi Du ; Xian-Bao Zhan ; Duo-Wu Zou ; Yan Liu ; Dong Wang ; Jie Chen ; Can Xu ; Zhao-Shen Li
• 关键词：CGN ; celiac ganglion neurolysis ; CPN ; celiac plexus neurolysis ; EUS-CGN ; EUS-guided celiac ganglion neurolysis ; NCPB ; neurolytic celiac plexus blockade ; PC ; pancreatic carcinoma ; SD ; standard deviation ; VAS ; Visual Analog Scale ; WHO ; World Health Organiza
• 刊名：Gastrointestinal Endoscopy
• 出版年：2012
• 出版时间：November, 2012
• 年：2012
• 卷：76
• 期：5
• 页码：945-952
• 全文大小：968 K

文摘

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Background

Celiac plexus neurolysis for the palliative reduction of pain in unresectable pancreatic carcinoma (PC) is safe but provides limited relief. In a previous study, we found that EUS-guided implantation of iodine-125 (¹²⁵I) around the celiac ganglia is a safe procedure and can induce apoptosis of local neurons in a porcine model.

Objective

To evaluate the safety and efficacy of direct celiac ganglion irradiation with ¹²⁵I seeds for the relief of moderate to severe pain secondary to unresectable PC.

Design

Prospective study.

Setting

Single, tertiary care referral center.

Patients

This study enrolled consecutive patients who had moderate to severe pain resulting from biopsy-proven unresectable PC.

Intervention

All patients underwent EUS-guided direct celiac ganglion irradiation with ¹²⁵I seeds. Follow-up was conducted at least once weekly until death.

Main Outcome Measurements

Blood parameters, Visual Analog Scale (VAS) score, mean analgesic (MS Contin [morphine sulfate]) consumption, and complications were evaluated during follow-up.

Results

Twenty-three patients with unresectable PC underwent the procedure. The mean number of seeds implanted in the celiac ganglion per patient was 4 (range 2-6). Immediately after the procedure, pain relief and analgesic consumption showed no significant changes compared with preoperative values. Six patients (26 % ) reported pain exacerbation. Two weeks later, the VAS score and mean analgesic consumption were significantly less than preoperative values. No procedure-related deaths or major complications occurred.

Limitations

Uncontrolled study.

Conclusions

EUS-guided direct celiac ganglion irradiation with ¹²⁵I seeds can reduce the VAS score and analgesic drug consumption in patients with unresectable PC.