The effect of oral micronized progesterone on hormonal and metabolic parameters in anovulatory patients with polycystic ovary syndrome

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• 作者：Sarantis Livadas ; Georgios Boutzios ; Fragiskos Economou ; Krystallenia Alex ; raki ; Xenofon Xyrafis ; Maria Christou ; Aristea Zerva ; Athanasios Karachalios ; Evangelia Tantalaki ; Evanthia Diamanti-K ; arakis
• 关键词：Androgens ; progesterone ; hyperandrogenism ; polycystic ovary syndrome ; HOMA-IR
• 刊名：Fertility and Sterility
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：94
• 期：1
• 页码：242-246
• 全文大小：168 K

文摘

Objective

To investigate the effects of oral natural micronized P on hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS) and to answer the clinical question whether induction of withdrawal bleeding is a necessity for the comparison of hormonal and metabolic data in subjects with PCOS.

Design

Prospective clinical study.

Setting

Academic medical center.

Patient(s)

Twenty-eight reproductive-aged women with PCOS.

Main Outcome Measure(s)

Blood sampling was collected at baseline, after 7 days of oral natural micronized P (200 mg) administration, and after withdrawal bleeding. At these three stages hormonal parameters and homeostasis assessment model (HOMA-IR) index were assessed in all patients.

Result(s)

Oral natural micronized P administration did not alter significantly insulin sensitivity index and androgen levels; however, LH was decreased when postbleeding values were compared to baseline. Nevertheless, after oral natural micronized P administration, P and 17α-hydroxyprogesterone (17-OHP) concentrations were increased, and HOMA-IR was decreased, whereas androgens levels were not altered, in comparison with baseline.

Conclusion(s)

The induction of withdrawal bleeding, with this regimen, does not appear to be a necessity for the assessment of hormonal and metabolic profile in anovulatory women with PCOS.