The emerging multiple roles of nuclear Akt

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• 作者：Alberto M. Martelli^a ; ^b ; ^{alberto.martelli@unibo.it} ; Giovanna Tabellini^c ; Daniela Bressanin^a ; Andrea Ognibene^d ; Kaoru Goto^e ; Lucio Cocco^a ; Camilla Evangelisti^b
• 关键词：Akt ; Nucleus ; Cell survival ; Cell proliferation ; Tumorigenesis ; mRNA export
• 刊名：Biochimica et Biophysica Acta (BBA)/Molecular Cell Research
• 出版年：2012
• 出版时间：December, 2012
• 年：2012
• 卷：1823
• 期：12
• 页码：2168-2178
• 全文大小：474 K

文摘

Akt is a central player in the signal transduction pathways activated in response to many growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of cellular functions including proliferation and survival, autophagy, metabolism, angiogenesis, motility, and exocytosis. Moreover, dysregulated Akt activity is being implicated in the pathogenesis of a growing number of disorders, including cancer. Evidence accumulated over the past 15 years has highlighted the presence of active Akt in the nucleus, where it acts as a fundamental component of key signaling pathways. For example, nuclear Akt counteracts apoptosis through a block of caspase-activated DNase: deoxyribonuclease and inhibition of chromatin condensation, and is also involved in cell cycle progression control, cell differentiation, mRNA: messenger RNA export, DNA repair, and tumorigenesis. In this review, we shall summarize the most relevant findings about nuclear Akt and its functions.