Folate and vitamin B12 levels in levodopa-treated Parkinson's disease patients: Their relationship to clinical manifestations, mood and cognition

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• 作者：Nikolaos I. Triantafyllou ; Chrysoula Nikolaou ; Fotini Boufidou ; Elias Angelopoulos ; Michael Rentzos ; Evangelia Kararizou ; Maria-Eleftheria Evangelopoulos ; Dimitrios Vassilopoulos
• 关键词：Vitamin B12 ; Brain lateralization ; Cognition ; Depression ; Folate ; Folic acid ; Parkinson's disease
• 刊名：Parkinsonism and Related Disorders
• 出版年：2008
• 出版时间：May 2008
• 年：2008
• 卷：14
• 期：4
• 页码：321-325
• 全文大小：111 K

文摘

We tested the hypothesis that mood, clinical manifestations and cognitive impairment of levodopa-treated Parkinson's disease (PD) patients are associated with vitamin B12 and folate deficiency. To this end, we performed this cross-sectional study by measuring serum folate and vitamin B12 blood levels in 111 consecutive PD patients. Levodopa-treated PD patients showed significantly lower serum levels of folate and vitamin B12 than neurological controls, while depressed patients had significantly lower serum folate levels as compared to non-depressed.