d="sp0010">Male OLETF rats were divided into 2 groups at 6 weeks of age. The first group received a standard diet until the end of experimental period at age 28 weeks. The second group was given a diet containing 0.05% atorvastatin from 6 weeks of age, before the onset of IR and pancreatic fibrosis. The age-matched Long–Evans Tokushima Otsuka rats without presence of IR, T2DM and pancreatic fibrosis, received a standard diet and were used as a normal control.
d="sp0015">Atorvastatin slightly decreased serum fasting glucose and insulin levels, but significantly improved index of IR compared with the untreated OLETF rats. In addition, atorvastatin markedly decreased transforming growth factor-β1 mRNA expression, myeloperoxidase activity and proportion of fibrotic area, and elevated superoxide dismutase activity in the pancreas compared with the untreated OLETF rats.
d="sp0020">These findings suggest that atorvastatin exerts favorable influence on progression of IR and pancreatic inflammation and fibrosis via pleiotropic effect such as anti-oxidative property.