Semisolids were obtained by thickening nanocapsule suspensions with gellan gum. The formulations presented characteristics suitable for cutaneous administration. NCP3 decreased MPO and NAGase activity in the UVB radiation-induced ear edema model. NC increased non-protein thiol levels and decreased lipid peroxidation induced by UVB radiation. NC with Q10 and VitE reduced the UVB irradiation-induced effects on skin.