2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists

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• 作者：David A. S ; ham ; Clive Aldcroft ; Urs Baettig ; Lucy Barker ; David Beer ; Gurdip Bhalay ; Zarin Brown ; Gerald Dubois ; David Budd ; Louise Bidlake ; Emma Campbell ; Brian Cox ; Brian Everatt ; David Harrison ; Ca
• 关键词：CRTh2 ; Prostaglandin D₂ ; Phenoxyacetic acid ; Eosinophils ; Allergic diseases
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2007
• 出版时间：1 August 2007
• 年：2007
• 卷：17
• 期：15
• 页码：4347-4350
• 全文大小：140 K

文摘

High throughput screening identified a phenoxyacetic acid scaffold as a novel CRTh2 receptor antagonist chemotype, which could be optimised to furnish a compound with functional potency for inhibition of human eosinophil shape change and oral bioavailability in the rat.