- 作者：Evert-Jan ter Borg MD ; PhD ; borg@antoniusziekenhuis.nl"" rel=""nofollow ; Anna P. Risselada MD† ; ; Johannes C. Kelder MD‡ ;
- 关键词：systemic autoantibodies ; extraglandular manifestations ; primary Sjö ; gren's syndrome
- 刊名：Seminars in Arthritis and Rheumatism
- 出版年：2011
- 出版时间：June 2011
- 年：2011
- 卷：40
- 期：6
- 页码：547-551
- 全文大小：165 K
Objectives
Extraglandular manifestations (EGM) are often seen in patients with primary Sjögren's syndrome and are probably due to a (more) disturbed immune system. Their relation to systemic autoantibodies remains controversial. We hypothesized that positive serology as reflected by the presence of 1 of more systemic autoantibodies is related to the number of EGM.Methods
To this purpose, all patients, visiting a large nonacademic teaching hospital, with primary Sjögren's syndrome, according to the revised American-European classification criteria of 2002, were retrospectively analyzed.
Results
In this group of 65 patients, systemic autoantibodies were abundant: anti-Sjögren syndrome A antigen (SSA) and/or anti-Sjögren syndrome B antigen (SSB) (80 % ), immunoglobulinM-Rheumatoid factor (IgM-RF) (68 % ), and anti-nuclear antibodies (ANA) (77 % ). Their presence was often found together and correlated to the presence of hypergammaglobulinemia. There was a statistically significant correlation between the number of systemic autoantibodies and the total number of EGM (P = 0.025). Anti-SSA was the strongest predictor of the presence of EGM (OR = 4.67, P = 0.024).
Conclusions
These findings indicate that a more disturbed immune system, as reflected by B-cell hyperactivity, with autoantibody formation and hypergammaglobulinemia, is associated with more systemic manifestations in patients with primary Sjögren's syndrome.