H-NS: an overarching regulator of the Vibrio cholerae life cycle

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• 作者：Julio C. Ayala^a ; ^b ; Anisia J. Silva^a ; ^{asilva-benitez@msm.edu} ; Jorge A. Benitez^a ; ^{jbenitez@msm.edu}
• 关键词：H-NS ; Vibrio cholerae ; Life cycle
• 刊名：Research in Microbiology
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：168
• 期：1
• 页码：16-25
• 全文大小：881 K
• 卷排序：168

文摘

Vibrio cholerae has become a model organism for studies connecting virulence, pathogen evolution and infectious disease ecology. The coordinate expression of motility, virulence and biofilm enhances its pathogenicity, environmental fitness and fecal-oral transmission. The histone-like nucleoid structuring protein negatively regulates gene expression at multiple phases of the V. cholerae life cycle. Here we discuss: (i) the regulatory and structural implications of H-NS chromatin-binding in the two-chromosome cholera bacterium; (ii) the factors that counteract H-NS repression; and (iii) a model for the regulation of the V. cholerae life cycle that integrates H-NS repression, cyclic diguanylic acid signaling and the general stress response.