Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults

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• 作者：Asger Bjerregaard^a ; ^b ; ^c ; ^{asger.bjerregaard@dadlnet.dk} ; Ingrid A. Laing^b ; ^c ; Nadia Poulsen^a ; ^b ; ^c ; Vibeke Backer^a ; Asger Sverrild^a ; Markus Fally^a ; Siew-Kim Khoo^b ; ^c ; Lucy Barrett^f ; Svetlana Baltic^f ; Philip J. Thompson^f ; Glenys Chidlow^d ; Chisha Sikazwe^d ; ^e ; David W. Smith^b ; ^d ; ^e ; Yury A. Bochkov^g ; Peter Le Souë ; f^c ; Celeste Porsbjerg^a
• 关键词：Asthma ; Exacerbation ; Eosinophils ; Viral infection ; TSLP
• 刊名：Respiratory Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：123
• 期：Complete
• 页码：34-41
• 全文大小：616 K
• 卷排序：123

文摘

Sputum eosinophils and FeNO are similar in virus-induced and non-viral exacerbations. Sputum eosinophils and FeNO correlate with FEV1 during exacerbation. TSLP correlate negatively with sputum eosinophils during virus-induced exacerbations.