Physical–chemical properties of plasma membrane and function of erythrocytes of cosmonauts after long-term space flight

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• 作者：S.M. Ivanova^a ; N.A. Brazhe^b ; ^{una@biophys.msu.ru} ; O.G. Luneva^b ; Y.V. Yarlikova^a ; O.I. Labetskaya^a ; E.Y. Parshina^b ; A.A. Baizhumanov^b ; G.V. Maksimov^b ; ^{maxim@biophys.msu.ru} ; B.V. Morukov^a
• 关键词：Erythrocyte ; Hemoglobin ; Plasma membrane fluidity ; Na/H-exchanger ; K_Ca-channel
• 刊名：Acta Astronautica
• 出版年：2011
• 出版时间：May-June 2011
• 年：2011
• 卷：68
• 期：9-10
• 页码：1517-1522
• 全文大小：490 K

文摘

We studied microfluidity and selective ion permeability of plasma membranes and O₂-binding properties of erythrocytes of cosmonauts during early rehabilitation after a long-term space flight (LTSF). Microfluidity of plasma membranes in surface regions was found to undergo a reversible decrease during 13–15 days following LTSF, which was accompanied by a reversible increase in relative cholesterol content. Cosmonauts’ erythrocytes revealed an increased activity of Na/H-exchanger and K_Ca-channel as well as a decrease in number of discocytes and increase in number of echinocytes, stomatocytes and knizocytes. Total hemoglobin content as well as oxyhemoglobin content were lowered after the LTSF, while the affinity of hemoglobin to O₂ was advanced. It is suggested that the changes in Hb properties, microfluidity and selective permeability of plasma membranes following the elevated cholesterol content in the membranes can decrease tissue supply with O₂.